Table 3.
Logistic regression modeling of potential predictors for CI.
| Variable | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Age | 1.060 (1.029–1.092) | < 0.001* | 1.043 (1.009–1.079) | 0.014* |
| Sex | 1.292 (0.743–2.249) | 0.364 | ||
| Education | 0.901 (0.835–0.972) | 0.007* | 0.930 (0.854–1.011) | 0.089 |
| Body mass index | 0.934 (0.866–1.007) | 0.075 | ||
| Current smoking | 0.756 (0.391–1.465) | 0.408 | ||
| Alcohol use | 0.681 (0.328–1.417) | 0.304 | ||
| Hypertension | 1.302 (0.746–2.272) | 0.352 | ||
| SBP | 1.013 (0.998–1.027) | 0.084 | ||
| DBP | 1.014 (0.991–1.037) | 0.240 | ||
| Diabetes | 2.288 (1.256–4.168) | 0.007* | 1.466 (0.705–3.047) | 0.306 |
| Coronary heart disease | 1.259 (0.587–2.700) | 0.553 | ||
| History of stroke | 1.651 (0.921–2.958) | 0.092 | ||
| Monocyte counts | 0.701 (0.256–1.923) | 0.491 | ||
| TC | 0.872 (0.679–1.122) | 0.287 | ||
| TG | 1.189 (0.805–1.756) | 0.385 | ||
| HDL | 0.571 (0.229–1.424) | 0.229 | ||
| LDL | 0.789 (0.559–1.113) | 0.177 | ||
| Uric acid | 1.000 (0.998–1.002) | 0.910 | ||
| Serum tHcy | 1.032 (0.990–1.076) | 0.140 | ||
| FPG | 1.261 (1.048–1.517) | 0.014* | 1.127 (0.908–1.399) | 0.278 |
| Severe CSVD burden | 4.066 (2.291–7.218) | < 0.001* | 2.456 (1.306–4.617) | 0.005* |
| MHR | 1.632 (1.222–2.180) | 0.001* | 1.462 (1.057–2.022) | 0.022* |
*p < 0.05. CI, cognitive impairment; SBP, systolic blood pressure; DBP, diastolic blood pressure; FPG, fasting plasma glucose; TC, total cholesterol; TG, triglyceride; HDL, high density lipoprotein; LDL, low density lipoprotein; tHcy, total homocysteine; MHR, monocyte to high-density lipoprotein cholesterol ratio; CSVD, cerebral small vessel disease.