Table 5.
Logistic regression modeling of potential predictors for severe CSVD burden.
| Variable | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Age | 1.066 (1.033–1.099) | < 0.001* | 1.083 (1.041–1.127) | < 0.001* |
| Sex | 1.977 (1.123–3.479) | 0.018* | 2.226 (1.025–4.839) | 0.043* |
| Education | 0.885 (0.819–0.956) | 0.002* | 0.854 (0.772–0.945) | 0.002* |
| Body mass index | 0.980 (0.921–1.043) | 0.526 | ||
| Current smoking | 1.390 (0.722–2.675) | 0.324 | ||
| Alcohol use | 1.842 (0.891–3.810) | 0.099 | ||
| Hypertension | 3.719 (2.042–6.775) | < 0.001* | 3.241 (1.516–6.928) | 0.002* |
| SBP | 1.029 (1.013–1.045) | < 0.001* | 1.010 (0.988–1.032) | 0.395 |
| DBP | 1.033 (1.009–1.057) | 0.007* | 1.042 (1.004–1.080) | 0.028* |
| Diabetes | 1.834 (1.014–3.316) | 0.045* | 1.397 (0.655–2.979) | 0.387 |
| Coronary heart disease | 1.132 (0.528–2.427) | 0.750 | ||
| History of stroke | 2.749 (1.512–4.999) | 0.001* | 1.817 (0.854–3.864) | 0.121 |
| Monocyte counts | 1.977 (0.434–9.001) | 0.378 | ||
| TC | 0.744 (0.574–0.965) | 0.026* | 0.950 (0.676–1.335) | 0.767 |
| TG | 1.376 (0.918–2.063) | 0.122 | ||
| HDL | 0.203 (0.047–0.552) | 0.002* | ||
| LDL | 0.722 (0.502–1.024) | 0.067 | ||
| Uric acid | 1.000 (0.998–1.001) | 0.664 | ||
| Serum tHcy | 1.044 (1.000–1.089) | 0.048* | 1.023 (0.969–1.081) | 0.414 |
| FPG | 1.170 (0.983–1.393) | 0.078 | ||
| MHR | 1.760 (1.309–2.365) | < 0.001* | 1.596 (1.092–2.334) | 0.016* |
*p < 0.05. SBP, systolic blood pressure; DBP, diastolic blood pressure; FPG, fasting plasma glucose; TC, total cholesterol; TG, triglyceride; HDL, high density lipoprotein; LDL, low density lipoprotein; tHcy, total homocysteine; MHR, monocyte to high-density lipoprotein cholesterol ratio; CSVD, cerebral small vessel disease.