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. 2002 Jan 22;99(3):1140–1145. doi: 10.1073/pnas.032646799

Figure 6.

Figure 6

17β-Estradiol stimulates the kinase activity of Cdk5. The bar charts show the initial rate activity of Cdk5 toward htau40, bovine τ, and histone H1 in immunoprecipitation kinase assays of forebrain extracts from control (Co) and at 0, 3, 6, and 12 h after heat shock. Note the enhanced overactivation of Cdk5 toward all three substrates and at all time points after heat shock in OVX + EB. Also, the Cdk5 activity toward htau40 in OVX + EB was significantly higher than in the other four groups. *, P < 0.05, a statistically significant difference in comparison with sham-OVX + SO.