Table 2.
Choroidal evaluation of pFTLD-Tau and pADNC patients.
| Unadjusted | Adjusted* | ||||||
|---|---|---|---|---|---|---|---|
| pFTLD-Tau (n = 25; 42 eyes) Mean(SE) | pADNC (n = 26; 49 eyes) Mean(SE) | P-Value | pFTLD-Tau (n = 25; 42 eyes) Mean(SE) | pADNC (n = 26; 49 eyes) Mean(SE) | Difference (95% CI) | P-Value | |
| Choroidal Thickness (microns) | |||||||
| Subfoveal | 308.9 (15.6) | 286.0 (19.1) | 0.35 | 315.7 (16.6) | 279.3 (22.7) | 36.4 (− 17.0, 89.7) | 0.18 |
| 500 microns (Inferior) | 292.6 (17.2) | 286.5 (19.2) | 0.81 | 308.2 (19.9) | 286.8 (21.8) | 21.5 (− 27.4, 70.3) | 0.39 |
| 500 microns (Nasal) | 294.0 (14.8) | 277.9 (17.7) | 0.49 | 304.3 (16.3) | 275.2 (20.8) | 29.1 (− 18.3, 76.4) | 0.23 |
| 500 microns (Superior) | 295.1 (16.3) | 292.5 (19.6) | 0.92 | 310.0 (20.3) | 290.4 (22.1) | 19.6 (− 30.1, 69.2) | 0.44 |
| 500 microns (Temporal) | 289.9 (13.2) | 278.4 (17.4) | 0.60 | 301.6 (14.1) | 276.2 (19.5) | 25.4 (− 21.4, 72.1) | 0.29 |
| 1000 microns (Inferior) | 291.8 (16.8) | 284.9 (19.9) | 0.79 | 307.5 (19.7) | 282.7 (21.0) | 24.8 (− 23.0, 72.6) | 0.31 |
| 1000 microns (Nasal) | 278.5 (13.9) | 268.9 (17.3) | 0.66 | 288.1 (15.3) | 263.6 (19.4) | 24.5 (− 22.1, 71.2) | 0.30 |
| 1000 microns (Superior) | 291.9 (14.7) | 294.7 (19.0) | 0.91 | 309.3 (18.9) | 296.0 (20.9) | 13.3 (− 34.8, 61.4) | 0.59 |
| 1000 microns (Temporal) | 291.3 (13.8) | 272.1 (16.3) | 0.37 | 295.9 (13.4) | 267.6 (18.8) | 28.3 (− 17.8, 74.4) | 0.23 |
| 1500 microns (Inferior) | 293.0 (16.8) | 280.3 (20.6) | 0.63 | 308.8 (19.1) | 276.1 (20.3) | 32.7 (− 18.1, 83.4) | 0.21 |
| 1500 microns (Nasal) | 255.0 (14.9) | 248.0 (16.8) | 0.76 | 264.1 (14.7) | 244.3 (18.8) | 19.8 (− 27.3, 66.9) | 0.41 |
| 1500 microns (Superior) | 285.6 (12.1) | 293.2 (18.5) | 0.73 | 304.4 (16.5) | 298.9 (20.3) | 5.5 (− 39.6, 50.6) | 0.81 |
| 1500 microns (Temporal) | 285.2 (14.5) | 267.1 (16.3) | 0.41 | 290.3 (12.6) | 266.7 (18.1) | 23.6 (− 24.2, 71.4) | 0.33 |
| Average of each of the point measurements of choroidal thickness | 292.5 (14.3) | 286.6 (18.7) | 0.80 | 304.7 (17.0) | 287.7 (20.3) | 17.0 (− 30.8, 64.8) | 0.49 |
| Choroidal Vascularity Index Parameters | |||||||
| Choroid luminal area (square pixels) | 337,184.8 (17,443.9) | 328,446.3 (21,829.7) | 0.75 | 348,633.4 (20,771.3) | 324,246.9 (25,441.4) | 24,386.5 (− 33,176.5, 81,949.5) | 0.41 |
| Choroid area (square pixels) | 465,682.6 (23,574.9) | 458,840.7 (30,606.4) | 0.86 | 488,878.2 (28,229.0) | 460,562.7 (33,245.2) | 28,315.5 (− 50,543.6, 107,175.0) | 0.48 |
| Choroidal vascularity index | 0.72 (0.01) | 0.72 (0.01) | 0.55 | 0.71 (0.01) | 0.71 (0.01) | 0.01 (− 0.02, 0.04) | 0.53 |
*Adjusted by age, sex, and race.
pADNC probable Alzheimer’s disease neuropathologic change, pFTLD-Tau probable frontotemporal lobar degeneration tauopathy, SE standard error.