Table 3.
Choroidal evaluation of pFTLD-Tau and normal controls.
| Unadjusted | Adjusted* | ||||||
|---|---|---|---|---|---|---|---|
| pFTLD-Tau (n = 25; 42 eyes) Mean(SE) | Normal Controls (n = 53; 80 eyes) Mean(SE) | P-Value | pFTLD-Tau (n = 25; 42 eyes) Mean(SE) | Normal Controls (n = 53; 80 eyes) Mean(SE) | Difference (95% CI) | P-Value | |
| Choroidal thickness (microns) | |||||||
| Subfoveal | 308.9 (15.6) | 301.5 (12.6) | 0.71 | 314.5 (17.1) | 291.6 (11.8) | 22.8 (− 16.7, 62.4) | 0.26 |
| 500 microns (Inferior) | 292.6 (17.2) | 283.0 (11.8) | 0.64 | 299.0 (16.7) | 275.1 (11.7) | 23.8 (− 14.0, 61.7) | 0.22 |
| 500 microns (Nasal) | 294.0 (14.8) | 299.7 (13.3) | 0.77 | 300.4 (16.2) | 289.7 (12.5) | 10.7 (− 28.3, 49.7) | 0.59 |
| 500 microns (Superior) | 295.1 (16.3) | 280.8 (11.3) | 0.47 | 299.6 (16.0) | 272.5 (11.0) | 27.1 (− 9.8, 64.0) | 0.15 |
| 500 microns (Temporal) | 289.9 (13.2) | 298.2 (12.5) | 0.65 | 301.1 (14.9) | 289.0 (11.3) | 12.1 (− 23.9, 48.1) | 0.51 |
| 1000 microns (Inferior) | 291.8 (16.8) | 284.8 (12.0) | 0.74 | 303.1 (16.9) | 278.0 (11.8) | 25.1 (− 13.3, 63.4) | 0.20 |
| 1000 microns (Nasal) | 278.5 (13.9) | 290.4 (13.4) | 0.54 | 288.0 (15.5) | 281.3 (12.6) | 6.7 (− 31.8, 45.2) | 0.73 |
| 1000 microns (Superior) | 291.9 (14.7) | 289.2 (11.7) | 0.89 | 299.3 (14.9) | 281.4 (10.9) | 17.9 (− 17.2, 53.0) | 0.32 |
| 1000 microns (Temporal) | 291.3 (13.8) | 294.8 (12.3) | 0.85 | 300.6 (15.6) | 285.6 (11.0) | 15.1 (− 20.6, 50.7) | 0.41 |
| 1500 microns (Inferior) | 293.0 (16.8) | 288.9 (11.8) | 0.84 | 304.3 (16.8) | 282.4 (11.6) | 22.0 (− 15.8, 59.7) | 0.25 |
| 1500 microns (Nasal) | 255.0 (14.9) | 263.1 (13.0) | 0.68 | 262.4 (15.7) | 254.6 (12.2) | 7.8 (− 31.1, 46.7) | 0.69 |
| 1500 microns (Superior) | 285.6 (12.1) | 290.6 (11.9) | 0.77 | 299.2 (13.2) | 283.2 (10.5) | 16.0 (− 15.9, 48.0) | 0.33 |
| 1500 microns (Temporal) | 285.2 (14.5) | 283.0 (11.0) | 0.91 | 291.0 (15.8) | 274.8 (10.3) | 16.2 (− 19.3, 51.7) | 0.37 |
| Average of each of the point measurements of choroidal thickness | 292.5 (14.3) | 293.1 (11.8) | 0.97 | 300.8 (15.4) | 284.2 (10.8) | 16.6 (− 19.3, 52.5) | 0.36 |
| Choroidal vascularity index parameters | |||||||
| Choroid luminal Area (square pixels) | 337,184.8 (17,443.9) | 338,560.5 (14,247.8) | 0.95 | 350,322.8 (19,321.7) | 325,122.8 (12,489.1) | 25,200.0 (− 18,841.2, 69,241.2) | 0.26 |
| Choroid area (square pixels) | 465,682.6 (23,574.9) | 466,322.7 (19,534.8) | 0.98 | 486,511.7 (25,832.2) | 448,035.2 (17,009.6) | 38,476.4 (− 21,677.2, 98,630.1) | 0.21 |
| Choroidal vascularity index | 0.72 (0.01) | 0.73 (0.01) | 0.86 | 0.72 (0.01) | 0.73 (0.01) | − 0.01 (− 0.03, 0.02) | 0.66 |
*Adjusted by age, sex, and race.
pFTLD-Tau probable frontotemporal lobar degeneration tauopathy, SE standard error.