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Model for transcriptional activation by GAL4-VP16. GAL4-VP16, together with PC4, stimulates the steps before initiation and the promoter escape step. The stimulation of promoter escape occurs through the ERCC3 helicase activity of TFIIH, possibly by directing nonproductive transcription complexes into the productive pathway. The productive complexes enter into elongation and produce the full-length transcript, whereas the nonproductive complexes may only produce abortive transcripts.
