Table 9.
Single dose Pharmacokinetic profile of atorvastatin, LIPITOR and solidified SNEDDS (mean ± SD, n = 3).
| Treatment groups | AUC0 − t (ng/ml*h) | Cmax (ng/ml) | Tmax (h) | t1/2 (h) | MRT (h) | Ke (h− 1) |
|---|---|---|---|---|---|---|
| Atorvastatin | 136.13 ± 16.75 | 11.738 ± 2.241 | 4 ± 0.00 | 7.278 ± 1.859 | 8.735 ± 0.824 | 0.095 ± 0.003 |
| LIPITOR | 220.06 ± 15.60 | 28.903 ± 3.187 | 2 ± 0.00 | 6.051 ± 1.873 | 7.272 ± 0.984 | 0.114 ± 0.001 |
| Solidified SNEDDS (SF10) | 305.98 ± 26.05 | 53.146 ± 5.707 | 2 ± 0.00 | 6.148 ± 2.628 | 6.339 ± 0.641 | 0.112 ± 0.002 |
MRT: mean residence time. AUC0−t: area under the plasma concentration−time plot from 0 h to time. Ke(h−1): elimination rate constant. t1/2: elimination half−life. Cmax: peak plasma drug concentration. Tmax: time at which Cmax was observed.