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Integrin inhibition activity of RGD-containing peptides
| IC50, nM (Q = ratio versus control peptide)
|
|||
|---|---|---|---|
| αIIbβ3 | αvβ3 | α5β1 | |
| IT1-COOH | 350 (0.21) | 380 (57) | 30,000 (1.0) |
| cyclo-IT1 | 210 (0.12) | 120 (18) | 400,000 (13) |
| IT2-COOH | 26,000 (15) | 230 (34) | 25,000 (0.83) |
| cyclo-IT2 | 2,300 (1.4) | 90 (24) | 600,000 (20) |
| IT3-COOH | 3,700 (2.2) | 40 (6.0) | 300,000 (10) |
| cyclo-IT3 | 460 (0.27) | 6.5 (0.97) | 300,000 (10) |
| GRGDSP (control) | 1,700 (1.0) | 6.7 (1.0) | 30,000 (1.0) |
