Figure 2.

(A) Hydropathy plot of Conus carboxylase aa sequence. The upper and lower cutoffs for tentative transmembrane segments are shown. The dotted arrow indicates a predicted transmembrane domain not evident in the Tie analysis (29). (B) Comparison of amino acid sequences of proposed Conus transmembrane domains derived from A to the corresponding human and Drosophila sequences. (C) Proposed topology of γ-glutamyl carboxylase originally proposed for the human enzyme by Stafford and coworkers (29).