Table 9.
PPIX plasma and brain homogenate stability results.
| Matrix | Stability | Bench Top | Freeze–Thaw | Autosampler | Processed Sample | Long-term | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| QC Level | LQC | HQC | LQC | HQC | LQC | HQC | LQC | HQC | LQC | HQC | |
| Nominal Conc. (nM) | 3.00 | 1500 | 3.00 | 1500 | 3.00 | 1500 | 3.00 | 1500 | 3.00 | 1500 | |
| Plasma | Period | 6 h | 2 cycles | 48 h | 4 h | 94 days | |||||
| Mean Conc. (nM) | 3.36 | 1720 | 3.22 | 1660 | 2.97 | 1480 | 3.14 | 1690 | 3.09 | 1580 | |
| Accuracy (%) | 112.1 | 114.7 | 107.3 | 110.7 | 99.1 | 98.7 | 104.7 | 112.7 | 103.0 | 105.3 | |
| CV (%) | 1.7 | 1.8 | 0.6 | 0.3 | 5.4 | 2.8 | 3.4 | 0.9 | 1.5 | 1.3 | |
| Brain Homogenate | Period | 4 h | 2 cycles | 72 h | 4 h | 98 days | |||||
| Mean Conc. (nM) | 3.05 | 1460 | 3.18 | 1630 | 3.01 | 1450 | 3.19 | 1620 | 3.32 | 1580 | |
| Accuracy (%) | 101.6 | 97.3 | 106.0 | 108.7 | 100.2 | 96.7 | 106.3 | 108.0 | 110.7 | 105.3 | |
| CV (%) | 3.3 | 6.7 | 7.7 | 4.4 | 2.0 | 1.6 | 2.6 | 0.7 | 4.4 | 1.3 | |