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. 2002 Jan 22;99(3):1280–1285. doi: 10.1073/pnas.032405199

Figure 1.

Figure 1

The design of 100 sequences compatible with the topology of 1ctf (A and C) and 1tim (B and D). A two-dimensional projection of the sequence space spanned by these sequences at the beginning of the optimization is shown in A and B, whereas C and D illustrate the size of this sequence space at then end of the optimization, after 80 cycles of SSA. (A–D) The position of the native sequence is set to the origin (0,0) and shown as a gray square. This two-dimensional representation of sequence space is created by using a nonlinear mapping procedure (23).