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. 2005 Sep 15;19(18):2152–2163. doi: 10.1101/gad.346105

Figure 2.

Figure 2.

Anxiety-like behavior in the elevated plus maze test. (A) Untreated TRα1 mutant mice (n = 16) showed an increased anxiety behavior compared with wild-type controls (n = 9) mice. (B) TRα1+/m (n = 7) mice treated with T3 as adults significantly ameliorated anxiety-like behavior in the elevated plus maze compared with wild-type mice (n = 9). (C) Injection of T3 during P10-P35 did not alleviate anxiety-like behavior of TRα1+/m (n = 6) compared with wild-type (n = 6) mice. Data were analyzed by means of a two-way (“genotype” × “T3 treatment”) ANOVA. Post hoc analysis showed that there was a statistically significant difference in the measured variables between mutant mice treated with T3 as adults and untreated mutant mice (all P < 0.01, Tukey's test). Data are presented as means ± SEMs; (★) P < 0.05; (★★) P < 0.01; (★★★) P < 0.001.