Table 3.

Differences in relative abundances at the family level by 16S rRNA sequencing in the gut microbiome of R and NR groups.

Family	Relative abundance (%)				p-value
	R		NR
Bifidobacteriaceae	2.96	[0.77, 9.83]	0.18	[0.09, 1.22]	0.045
Coriobacteriaceae	0.62	[0.26, 1.40]	0.42	[0.13, 2.26]	0.800
Eggerthellaceae	0.25	[0.15, 0.45]	0.08	[0.06, 0.43]	0.340
Bacteroidaceae	19.46	[11.04, 28.71]	30.17	[18.89, 37.98]	0.261
Barnesiellaceae	0.37	[0.03, 1.13]	0.00	[0.00, 1.00]	0.306
Marinifilaceae	0.33	[0.06, 0.69]	0.37	[0.16, 0.56]	1.000
Prevotellaceae	0.68	[0.01, 2.92]	6.28	[0.01, 12.60]	0.650
Rikenellaceae	1.31	[0.55, 3.63]	0.79	[0.45, 2.44]	0.592
Tannerellaceae	3.83	[1.43, 4.25]	3.06	[2.19, 3.71]	0.902
Desulfovibrionaceae	0.11	[0.03, 0.20]	0.11	[0.04, 0.14]	0.553
Erysipelatoclostridiaceae	0.35	[0.17, 1.09]	0.35	[0.23, 1.61]	0.536
Erysipelotrichaceae	0.57	[0.25, 1.20]	0.72	[0.19, 2.01]	0.773
Lactobacillaceae	0.16	[0.01, 0.52]	0.10	[0.01, 0.20]	0.650
Streptococcaceae	3.06	[0.78, 9.07]	1.37	[0.60, 4.39]	0.592
Christensenellaceae	0.14	[0.05, 0.93]	0.04	[0.01, 0.06]	0.090
Clostridiaceae	0.32	[0.02, 1.21]	0.03	[0.01, 0.46]	0.271
Lachnospiraceae	18.50	[13.04, 23.54]	24.27	[20.25, 28.43]	0.142
Monoglobaceae	0.10	[0.01, 0.12]	0.03	[0.00, 0.19]	0.865
Butyricicoccaceae	0.10	[0.05, 0.22]	0.14	[0.06, 0.24]	0.592
Oscillospiraceae	2.97	[0.87, 4.05]	0.86	[0.65, 1.11]	0.120
Ruminococcaceae	8.37	[4.61, 10.71]	1.94	[1.26, 4.87]	0.056
Anaerovoracaceae	0.21	[0.08, 0.36]	0.14	[0.05, 0.30]	0.612
Peptostreptococcaceae	0.98	[0.19, 1.64]	0.50	[0.09, 1.67]	0.902
Acidaminococcaceae	0.19	[0.01, 0.40]	1.03	[0.00, 1.22]	0.520
Veillonellaceae	0.15	[0.02, 0.49]	0.06	[0.01, 2.63]	0.773
Sutterellaceae	0.26	[0.00, 0.93]	0.03	[0.00, 0.64]	0.670
Enterobacteriaceae	0.37	[0.07, 0.76]	0.62	[0.21, 2.49]	0.711

R responder, NR non-responder.

Data are expressed as median [interquartile range]. Only families with median abundance above 0.1% are shown.

p-values were estimated using the Mann–Whitney U test. p-value entries in bold indicate p < 0.05.