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. 2002 Jan 29;99(3):1651–1656. doi: 10.1073/pnas.042416199

Figure 4.

Figure 4

Modulation of nociceptive responses by intrathecal administration of an antibody to TIP39 or TIP39 itself. Tail-flick (a, d), paw pressure (b, e), and Hargreaves' (radiant heat directed to a paw; c, f) assays were performed as described in Materials and Methods. Responses after intrathecal delivery of vehicle (Veh), antibody to TIP39 (α-TIP), or preimmune serum (Pre Imm) are shown at 30 min after injection, the time at which the largest effect of the antibody was observed (a–c). Responses at various times after injection of vehicle or 100 fmol of TIP39 (TIP39) are shown (d–f).