Table 5.
Recoveries and matrix effects of simnotrelvir, ritonavir and urea
| Group | Simnotrelvir | Ritonavir | Urea | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Low (10 ng/mL) | Medium (100 ng/mL) | High (1000 ng/mL) | Low (2 ng/mL) | Medium (50 ng/mL) | High (500 ng/mL) | Low (100 μg/mL) | Medium (200 μg/mL) | High (400 μg/mL) | |
| Recoveries of serum (%) | 88.31 | 90.45 | 91.15 | 97.43 | 101.44 | 109.71 | 92.23 | 101.51 | 101.12 |
| Recoveries of BALF (%) | 98.28 | 99.08 | 92.97 | 93.02 | 105.70 | 104 | 97.61 | 109.75 | 109.75 |
| Matrix effects of serum (%) | 89.51 | 95.15 | 85.67 | 108.93 | 107.04 | 103.98 | 95.43 | 95.16 | 100.93 |
| Matrix effects of BALF (%) | 89.92 | 94.94 | 89.45 | 98.70 | 98.52 | 87.10 | 98.41 | 93.46 | 99.61 |