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. 2002 Jan 22;99(3):1677–1682. doi: 10.1073/pnas.022641099

Figure 1.

Figure 1

Modulation of CIA in the rat by prednisolone and the GC derivatives. (A) Chemical structure of prednisolone and the chains added to position 21 to yield either NCX-1015 or NCX-1016. (B–D) Rats were treated daily i.p. with NCX-1015 (▴, 4 μmol/kg; ▵, 0.4 μmol/kg), prednisolone (●, 4 μmol/kg; ○, 0.4 μmol/kg), NCX-1016 (♦, 4 μmol/kg) or vehicle (■, 100 μl peanut oil) from day 12 to day 18 after collagen II injection. A group of naïve rats (□) also was used. During the development of the arthritis, plethysmometry was used to assess paw volume (B), and rats' paws and ankles were individually assessed and scored (C), as described in Materials and Methods. After killing the animals (day 18), anklebone thickness was measured with calipers (D). Data are expressed as means ± SEM (n = 10 per group). *, P ≤ 0.05 vs. vehicle-treated group and #, P ≤ 0.05 vs. naïve animals.