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. 2002 Jan 22;99(3):1677–1682. doi: 10.1073/pnas.022641099

Figure 3.

Figure 3

Effect of CIA and GC treatment on serum levels of cytokines and pyridinoline. (A–C) Prednisolone (Pred), NCX-1015, NCX-1016, or vehicle (V) treatment was the same as in Fig. 1 (i.p. from day 12 at the indicated doses in μmol/kg), whereas in D, drugs or vehicle (V) were given orally. A group of naïve rats also was used. (A) IL-1β, (B) IL-6 and (C and D) pyridinoline concentration as measured by using specific ELISA. Data are expressed as means ± SEM (n = 10 per group). *, P ≤ 0.05 vs. vehicle-treated group and #, P ≤ 0.05 vs. naïve animals.