Table 2.
Competing risk regression model for CTCAE grade ≥ 2 cardiac events
| Variable | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age | 1.05 (1.01–1.10) | 0.024 | 1.07 (0.99–1.15) | 0.051 |
| BMI | 1.09 (0.98–1.20) | 0.11 | ||
| Tobacco | ||||
| Never | 1.0 (Reference) | |||
| Ever | 0.98 (0.26–3.73) | 0.98 | ||
| Hypertension | 0.54 (0.07–4.01) | 0.55 | ||
| Hyperlipidemia | 1.46 (0.32–6.72) | 0.62 | ||
| CV medications | ||||
| Any antihypertensive | 0.54 (0.07–4.01) | 0.55 | ||
| Statin | 1.65 (0.36–7.54) | 0.52 | ||
| Anti-platelet | 1.67 (0.23–12.16) | 0.61 | ||
| CAC score | ||||
| CAC = 0 | 1.0 (Reference) | 1.0 (Reference) | ||
| CAC > 0 | 2.11 (0.40-11.03) | 0.38 | 1.43 (0.11–18.13) | 0.78 |
| Chemotherapy | ||||
| Doxorubicin | † | - | ||
| Cyclophosphamide | † | - | ||
| Carboplatin | † | - | ||
| Taxane | † | - | ||
| Capecitabine | 0.39 (0.05–3.22) | 0.38 | ||
| Mastectomy | 0.86 (0.24–3.16) | 0.82 | ||
| RT dose | ||||
| Mean heart dose (per Gy) | 1.16 (0.93–1.44) | 0.18 | ||
| Mean LAD dose (per Gy) | 1.16 (1.03–1.31) | 0.015 | 1.16 (1.01–1.35) | 0.041 |
Abbreviations: HR, hazard ratio; CI, confidence interval; BMI, body mass index; CV, cardiovascular; CAC, coronary artery calcium; RT, radiation therapy; LAD, left anterior descending coronary artery. †All failure events occurred in these groups, infinitely large hazard ratio, omitted from model