. 2025 Jul 4;25:269. doi: 10.1186/s12880-025-01820-z

Table 3.

Diagnostic performance for ACR TI-RADS and revisions of thyroid nodule size criteria

Indicator	Sensitivity (95% CI)	Specificity (95% CI)	AUC (95% CI)	P	Unnecessary Biopsy	Missed Malignancy
ACR TI-RADS	76.5% (62.5-87.2%)	75.2% (67.5-81.8%)	0.825 (0.756–0.894)	/	38	12
Strategy 1	82.4% (69.1-91.6%)	65.4% (57.3-72.9%)	0.831 (0.768–0.895)	0.36^*	53	9
Strategy 2	88.2% (76.1-95.6%)	53.6% (45.4-61.7%)	0.799 (0.737–0.860)	0.86^*	71	6

Indicator

Sensitivity
(95% CI)

Specificity
(95% CI)

AUC
(95% CI)

Unnecessary
Biopsy

Missed
Malignancy

ACR

TI-RADS

76.5%

(62.5-87.2%)

75.2%

(67.5-81.8%)

0.825

(0.756–0.894)

Strategy 1

82.4%

(69.1-91.6%)

65.4%

(57.3-72.9%)

0.831

(0.768–0.895)

0.36^*

Strategy 2

88.2%

(76.1-95.6%)

53.6%

(45.4-61.7%)

0.799

(0.737–0.860)

0.86^*

Abbreviations: ACR, American College of Radiology; AUC, area under the receiver operating characteristic curve; CI, confidence interval; TI-RADS, Thyroid Imaging Reporting and Data System

* Compared with the ACR TI-RADS