Table 1. Baseline characteristics by quarters of age.
| Age groups (years) | P value | ||||
|---|---|---|---|---|---|
| <67(n=285) | ≥67–≤73 (n=284) | >73–≤79 (n=283) | >79(n=285) | ||
| Age (years) | 60 (55, 64) | 72 (67, 72) | 76 (75, 78) | 83 (81, 86) | – |
| Women | 85 (30) | 84 (30) | 62 (22) | 69 (24) | 0.077 |
| White | 242 (85) | 265 (93) | 262 (93) | 274 (96) | <0.001 |
| Recruitment context | 0.93 | ||||
| In hospital | 38 (13) | 42 (15) | 39 (14) | 45 (16) | |
| Recent discharge | 58 (21) | 49 (17) | 49 (17) | 52 (18) | |
| Ambulatory patient | 189 (66) | 193 (68) | 195 (69) | 188 (66) | |
| Systolic BP (mm Hg) | 114 (103, 130) | 118 (106, 132) | 122 (109, 133) | 120 (108, 132) | 0.003 |
| LVEF (%) | 30 (25, 35) | 35 (27, 38) | 35 (28, 38) | 34 (25, 39) | 0.001 |
| BMI | 29.0(24.9–33.5) | 29.7(25.9–33.8) | 28.1(24.6–32.3) | 27.0(23.6–29.9) | <0.001 |
| NYHA III/IV | 107 (38) | 120 (42) | 121 (43%) | 141 (49) | 0.038 |
| Ischaemic aetiology | 154 (54) | 168 (59) | 159 (56) | 166 (58) | 0.61 |
| Atrial fibrillation | 85 (30) | 132 (46) | 153 (54) | 164 (58) | <0.001 |
| Hypertension | 120 (42) | 159 (56) | 170 (60) | 163 (57) | <0.001 |
| Diabetes | 139 (49) | 143 (50) | 137 (48) | 102 (36) | 0.001 |
| Hb (g/dL) | 12.3 (11.2, 12.9) | 12.1 (11.3, 12.9) | 12.1 (11.2, 12.8) | 11.8 (11.1, 12.7) | 0.079 |
| TSAT (%) | 15 (10, 19) | 15 (11, 20) | 16 (11, 19) | 16 (11,21) | 0.32 |
| TSAT <20% | 221 (79) | 207 (75) | 208 (76) | 205 (73) | 0.44 |
| Ferritin (ng/mL) | 54 (28, 90) | 48 (28, 82) | 48 (31, 85) | 49 (30, 84) | 0.77 |
| eGFR (mL/min/1.73 m2) | 64 (48, 86) | 54 (39, 71) | 47 (37, 73) | 44 (34, 55) | <0.001 |
| NT-proBNP (ng/L)* | 1203 (607, 3023) | 1414 (820, 2823) | 1686 (964, 3602) | 2745 (1570, 4822) | <0.001 |
Continuous variables are summarised as median (lower quartile, upper quartile) and categorical variables as counts and percentages.
*
NT-proBNP was recorded only in a subset of ambulatory patients: 142, 136, 144 and 143 patients had NT-proBNP recorded for age groups <67 years, ≥67–≤73 years, >73–≤79 years and >79 years, respectively.
BMI, body mass index; BP, blood pressure; eGFR, estimated glomerular filtration rate; FDI, intravenous ferric derisomaltose; Hb, haemoglobin; LVEF, left ventricular ejection fraction; NT-proBNP, N-terminal-pro B-type natriuretic peptide; NYHA, New York Heart Association; TSAT, transferrin saturation.