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. 2025 Jul 4;8:995. doi: 10.1038/s42003-025-08434-9

Fig. 7. Uterine stromal MEN1 regulates stromal decidualization and epithelial differentiation.

Fig. 7

Menin in stromal cells maintains the gene expression of WNT repressors SFRP2 and DKK1 through H3K4me3, thereby effectively limiting the overactivation of WNT signaling pathway and supporting the normal decidualization. HAND2 mediates stromal-epithelial crosstalk via FGF signaling, while stromal Menin deficiency disrupts this paracrine axis by suppressing HAND2, thereby impairing epithelial differentiation. Thus, Menin plays a crucial role in regulating endometrial receptivity and facilitating embryo implantation.