Table 5.
Risk Factors to Composite Cardiovascular Outcomesa in Female with Panhypopituitarism
| Variable | Univariate (n=2,287) |
Multivariate (n=2,287) |
||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Age | 1.05 (1.04–1.05) | <0.001 | 1.04 (1.03–1.05) | <0.001 |
| Diabetes mellitus | 1.91 (1.47–2.47) | <0.001 | 1.35 (1.02–1.77) | 0.033 |
| Hypertension | 2.46 (1.99–3.03) | <0.001 | 1.59 (1.25–2.01) | <0.001 |
| Dyslipidemia | 1.65 (1.34–2.04) | <0.001 | 1.16 (0.93–1.45) | 0.196 |
| Brain surgery | 0.84 (0.66–1.06) | 0.143 | - | - |
| Radiation therapy | 1.23 (0.58–2.59) | 0.593 | - | - |
| Radiosurgery | 0.82 (0.49–1.38) | 0.457 | - | - |
| Growth hormone | 0.23 (0.07–0.71) | 0.011 | 0.29 (0.09–0.92) | 0.035 |
| Sex hormone | 0.43 (0.31–0.59) | <0.001 | 0.74 (0.53–1.03) | 0.074 |
| Desmopressin | 0.74 (0.55–0.98) | 0.037 | 1.01 (0.75–1.36) | 0.950 |
| Craniopharyngioma | 0.88 (0.62–1.25) | 0.471 | - | - |
OR, odds ratio; CI, confidence interval.
a
Composite cardiovascular outcome: coronary artery disease or ischemic stroke or intracranial hemorrhage or heart failure.