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MSC bundles guide host neuropil. (A–C) Beyond the astrocytic scar surrounding the epicenter of the lesion (A), nestin-positive (blue) and GFAP-negative immature astrocytes (B) are found closely associated with transplanted MSC (C). (D–F) Neurofilament-IR fibers (red) are found in close relationship with nestin-IR fibers (blue) mainly in the periphery of MSC bundles. (Bars = 25 μm.)
