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. 2002 Feb 19;99(4):2205–2210. doi: 10.1073/pnas.042688499

Table 1.

Effect of E2 treatment on body and uterine weights, serum estradiol, aortic contraction (in response to KCl, phenylephrine, and U-46619), basal endothelial NO release, and aortic relaxation in response to acetylcholine from ovariectomized ERα-WT, ERα-Δ2 KO, and ERα-Neo KO mice given either placebo or E2

Phenotype treatment ERα-WT
ERα-Neo KO
ERα-Δ2 KO
Placebo E2 Placebo E2 Placebo E2
Body weight, g 28.1  ± 2.7 24.1  ± 2.1 23.2  ± 1.9 22.7  ± 1.2 20.6  ± 2.6 23.3  ± 1.6
Uterine weight, mg <20 151  ± 26 <20 42  ± 16 <20 <20
Plasma E2, pg/ml <5 162  ± 26 <5 151  ± 25 <5 158  ± 40
Maximal contraction, mg
 KCl, 80 mM 691  ± 31 678  ± 28 740  ± 21 773  ± 66 694  ± 35 830  ± 57
 Phe, 3 μM 1177  ± 83 897  ± 94 714  ± 83 583  ± 61 700  ± 41 842  ± 78
 U46619, 7.5 nM 739  ± 58 801  ± 77 690  ± 64 695  ± 97 783  ± 155 750  ± 139
Basal NO, mg 403  ± 51 579  ± 72* 361  ± 46 503  ± 53* 427  ± 55 413  ± 67
ACh-elicited relaxation
 EC50, 10−8 M 5.87  ± 0.88 13.79  ± 2.60* 6.99  ± 4.9 27.48  ± 3.87* 10.23  ± 6.52 6.23  ± 2.06
 Emax, % relaxation 90.3  ± 2.3 63.8  ± 3.5* 87.3  ± 1.9 60.7  ± 7* 89.6  ± 4.0 96.5  ± 5.6

Data for ERα-Δ2 KO mice have been published (20). Data are means ± SE from the two distal rings of the thoracic aorta from five separate mice in each group. 

*

, P < 0.05 vs. respective placebo.