Table 1. Capsid insert sequences.
This table lists the peptide insertions in the AAV2/5 VP1 capsid that were most recovered from infected PDGFRA-Cre hGPCs after Cre-mediated recombination, comprising the 20 most human glial-selective peptide sequences that we recovered (see also Figure 1). CM1, 6, 11 and 16 (in bold) were the most human and glial selective among the recovered capsid inserts; among these, CM1 and CM6 were those that survived filtration against systemic organs, that exhibited the greatest human selectivity, and which infected most efficiently.
| ID | Peptide sequence |
|---|---|
| CM1 | TLRDSTT |
| CM2 | LKPAQCK |
| CM3 | TNPENAR |
| CM4 | HRHFTCL |
| CM5 | VTPDQTY |
| CM6 | PRTTVSN |
| CM7 | GPNLHAR |
| CM8 | HISRPGI |
| CM9 | ELKCVTR |
| CM10 | SPQLATY |
| CM11 | SELYAYV |
| CM12 | RTAPLST |
| CM13 | VYAQIPT |
| CM14 | NGVALKE |
| CM15 | RRSRTIS |
| CM16 | TTSCAAS |
| CM17 | ERTRRDD |
| CM18 | KNPPGPT |
| CM19 | KVSGNQN |
| CM20 | DQAPMLF |