Table 2: Predictor Effects on the Association of SLIT2 Vitreous and MoCA Score.

The single predictor model applied each variable separately to determine its individual impact on the association of SLIT2 Vitreous and MoCA Score. In the multiple predictor model, all demographic variables (age, sex, and race) were additionally combined with medical variables. APOE genotype and risk category were not included in the multiple predictor or complete models because the single predictor model did not find a significant association. The complete model did meet statistical significance (p=0.0141) with a large effect size (f²=0.391) and sufficient power (92.5%, f²=0.2, α=0.05).

Effect	Estimate	Standard Error	Confidence Interval (95%)	P
Single Predictor
Age	0.003743	0.00179	0.000147 to 0.007338	0.0416
Sex	0.004392	0.00180	0.0007784 to 0.008006	0.0181
Race	0.004022	0.00189	0.0002259 to 0.007818	0.0382
Diabetic Status	0.004088	0.00184	0.0004033 to 0.007773	0.0303
Diabetic Retinopathy Status	0.003779	0.00181	0.0001360 to 0.007422	0.0423
Glaucoma	0.004361	0.00186	0.0006289 to 0.008094	0.0228
APOE Genotype	0.003007	0.00184	−0.0007016 to 0.006715	0.1096
APOE Risk Category	0.003172	0.00181	−0.0004808 to 0.006825	0.0872
Multiple Predictor
Demographics	0.004345	0.00184	0.0006379 to 0.008051	0.0225
Demographics + Diabetic Status	0.004735	0.00190	0.0009117 to 0.008559	0.0162
Demographics + Diabetic Retinopathy Status	0.004299	0.00188	0.0005113 to 0.008087	0.0269
Demographics + Glaucoma	0.005080	0.00193	0.001211 to 0.008948	0.0111
Complete Model	0.004991	0.00196	0.0001052 to 0.008930	0.0141

Diabetic Status: Non-Diabetic (reference group), Type 1 Diabetes, Type 2 Diabetes

Diabetic Retinopathy Status: No Diabetic Retinopathy (reference group), Proliferative

Diabetic Retinopathy

Glaucoma: No glaucoma (reference group), Glaucoma

APOE Genotype: 3/3 (reference group), 2/2, 2/4, 3/4, 4/4

APOE Risk Category (see Supplementary Table 1): 2/3 and 3/3 (reference group), 2/2, 2/4 and 3/4, 4/4