Table 1.

Daily Clinical Parameters and Laboratory Values

	Day 1	Day 2	Day 3	Day 4	Reference Range
Severity scores
SOFA score	7	10	5	3	0-24
APACHE II	—	24	—	—	0-71
Laboratory values
Hemoglobin, g/dL	11.4	10.3	9.8	8.3	11.7-15.3
White blood cell count, ×103/μL	4.1	1.7	6.2	11.0	3.5-8.8
Platelet count, ×103/μL	217	178	206	177	165-387
Hematocrit, %	34	30	29	24	36-48
Creatinine, mg/dLa	6.55	4.40	2.36	1.46	<1.02
Estimated GFR, mL/min/1.73 m2	7	11	20	34	>60
Bilirubin, mg/dL	0.94	0.64	0.58	0.58	<1.5
Procalcitonin, ng/mL	—	24	—	—	<0.5
C-reactive protein, mg/L	490	489	490	280	<3
Hs-cTnT, ng/Lb	—	1) 24 2) 43	(3) 19	—	<15
NT-proBNP, pg/mLc	—	13,900	—	—	<222
Arterial lactate, mmol/L	3.2	1.9	1.8	0.8	0.5-2.3

Apache II = Acute Physiology and Chronic Health Evaluation II; GFR = glomerular filtration rate; hs-cTnT = high-sensitivity cardiac troponin T; NT-proBNP = N-terminal pro–B-type natriuretic peptide; SOFA = Sequential Organ Failure Assessment.

^aThe patient’s habitual creatinine level before hospitalization was 0.96 mg/dL (estimated GFR, 58 mL/min/1.73 m²).

^bFor hs-cTnT, measurements were sampled at 3-hour intervals: 1) day 2, 19:00; 2) day 2, 22:00; 3) day 3, 01:00.

^cNT-proBNP was measured on day 2 at 19:00.