Table 1.
comparison of DFL and cFL
| DFL | cFL | |
|---|---|---|
| Lymph node involves | Almost no enlarge lymph nodes | Always enlarge lymph nodes |
| Location | Small intestine, particularly the second part of the duodenum | Lymph node or extra-node sometimes |
| Neoplastic involvement | Duodenal villi | submucosa and subserosa |
| Lesion manifestations | Multiple small polyps or nodules | Enlarge lymph-nodes |
| Grade | I or II | I or II |
| Bcl-6 | + | + (part -) |
| CD10 | + | + (part -) |
| Bcl-2 | + | + |
| CD21 | In the germinal center, less than 10% of the neoplastic germinal center | At other extranodal sites, more than 2/3 of the neoplastic germinal center |
| CD27 | + | – |
| AID | – | + |
| T(14;18) | + | + |
| Ki-67 | ± | ± |
| IgVH use | V4, V5 | V3, most cases |
| TNFRSF14/HVEM | + | + |
| CREBBP | + | + |
| KMT2D/MLL2 | – | High mutation frequency in advanced systemic FL |
| Genes associated with inflammatory processes | + | + in early-stage low-grade systemic FL |