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. 2025 Jun 25;17:1546977. doi: 10.3389/fnagi.2025.1546977

Table 2.

Brain regions with reduced cortical thickness in the AD-HC groups.

Cluster Hemisphere T-value Size Peak MNI coordinate Mean CT in AD group (mm) Mean CT in HC group (mm) Overlap of atlas Region
Cluster 1 L 4.6 472 −46, −26, 7 2.23 ± 0.14 2.39 ± 0.15
38% Left transverse temporal
49% Left superior temporal
12% Left supramarginal
1% Left insula
Cluster 2 R 5.0 1,365 41, −22, 6 2.77 ± 0.23 3.01 ± 0.17
39% Right superior temporal
12% Right temporal pole
8% Right entorhinal
10% Right transverse temporal
14% Right insula
9% Right supramarginal
5% Right fusiform

AD, Alzheimer’s disease; HC, Health control; CT, Cortical thickness.