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Deregulation of the p53 network in cancer cells. Dysfunctional p53 will not bind to the response element localized in the promoters of all p53‐regulated genes, including p21. Impairing this transcriptional pathway (left part of the Fig.) prevents the activation of the various p53 response genes. Lack of p21 induction also impairs the DREAM pathway (right part of the Fig.), leaving multiple genes repressed by the DREAM complex, as shown in Fig. 3.
