Table 5.
Effects of fish and perilla oil on rat brain gene expression and genes with altered gene expression
| Fish oil Mean SD Fold-Δ | Perilla oil Mean SD Fold-Δ | Gene product | Acc. no. |
|---|---|---|---|
| Lipid metabolism | |||
| 5.65 1.45 | 4.13 0.79 | Serine palmitoyl transferase | AF111168 |
| 5.35 0.85 | 5.23 1.29 | Farnesyl pyrophosphate syn. (testis) | NM_031840 |
| −3.34 0.11 | −3.89 0.1 | Dihydrolipoamide transacylase E2 | AA410009 |
| −1.74 nd | −2.09 0.02 | Phospholipase D | D8862 |
| Membrane proteins | |||
| 6.39 2.4 | 6.03 0.52 | Sec24 prot. (Sec24A isoform) | AJ131244 |
| 1.52 0.25 | 1.92 0.05 | B cell receptor ass. prot. 37 | U75392 |
| −1.9 0.02 | −1.98 0.1 | Syntaxin binding prot. Munc18-2 | U20283 |
| −2.94 0.13 | −4.76 0.19 | Transthyretin | NM_012681 |
| −3.04 0.06 | 1.17 nd | Membrane prot. (human ch. 3p25) | L09260 |
| Endocytosis, synaptic vesicle recycling, formation | |||
| 2.05 0.03 | 2.02 0.45 | D-cadherin precursor | AF135156 |
| 4.5 0.35 | 5.23 0.23 | Clathrin-ass. adaptor chain mu 1A | AF139405 |
| 3.15 0.89 | 3.12 0.36 | Adaptor-rel. prot. AP-3 mu2 subunit | L07074 |
| 1.72 0.17 | 2.16 0.22 | Profilin IIa (Pfn2) | AF228737 |
| Synaptic proteins | |||
| 1.97 0.21 | 2.03 0.23 | Synuclein, alpha | NM_019169 |
| 2.37 0.27 | 2.34 0.21 | Synuclein, gamma | NM_031688 |
| Cytoskeleton | |||
| 2.58 nd | 2.97 nd | Actin-rel. prot. 2 | XM_002674 |
| 1.78 0.11 | 1.89 0.47 | Alpha-tubulin (Tuba1) | NM_022298 |
| 1.25 0.38 | 2.02 0.32 | Microtubule-ass. prot. 1A/1B chain 3 | NM_022867 |
| −1.5 0.12 | −2.09 0.27 | Axoneural dynein heavy chain 8 | U61747 |
| −1.62 0.09 | −1.65 0.15 | Microtubule-ass. prot. 4 | AW142042 |
| −2.57 0.11 | −4.95 0.03 | Unconventional myosin 3 (Myr5) | NM_012981 |
| −2.13 0.04 | −2.86 0.03 | Capping prot. (actin filament) | AW541453 |
| Signal transduction | |||
| 2.66 1.12 | 2.86 0.89 | RAB6B small GTPase | W17800 |
| 1.68 0.13 | 1.98 0.43 | Calmodulin (RCM3) | NM_017326 |
| 1.93 0.24 | 2.3 0.27 | Calmodulin 1 (Calm 1) | NM_031969 |
| 1.79 0.14 | 1.8 0.13 | Calmodulin | AF178845 |
| 1.62 0.21 | 1.79 0.2 | LIM-domain prot. LMP-1 | AF095585 |
| 2.99 0.07 | 3.63 0.28 | SH3-containing prot. SH3P4 | AF009603 |
| 2.13 0.36 | 2.11 0.33 | Pleiotrophin (Hbnf, HB/GAM) | NM_017066 |
| −2.21 0.03 | nd nd | Bromodomain prot. CELTIX1 | AF213969 |
| −1.65 0.2 | −1.3 0.22 | Ajuba (Jub) (M. musculus) | AW536166 |
| −2.53 0.11 | −2.86 nd | L1cam locus (M. musculus) | AA409744 |
| −1.43 0.15 | −1.76 0.07 | Ras oncogene neuroblastoma, Nras | W15662 |
| Others | |||
| 1.91 0.51 | 2.04 0.34 | Translin | NM_021762 |
| 6.57 2.17 | 7.7 2.14 | Ubiquitin-prot. ligase Nedd4-2 | AF277232 |
| 2.99 0.8 | 2.36 1.1 | Parathyroid hormon reg. sequence | AA290355 |
| 4.42 2.1 | 6.28 1.58 | Elongation factor 1-alpha | X63561 |
| 4.37 2.04 | 5.44 0.97 | Beta-globin | X16417 |
| 4.14 1.27 | 5.6 nd | Ribosomal prot. L7a | X15013 |
| 1.91 0.17 | 1.64 nd | Dipeptidyl peptidase III | D89340 |
| −1.59 nd | −1.96 0.7 | RNA-binding prot. AB0169092 | AA038452 |
| −5.24 0.02 | −2.62 0.24 | U1 small nuclear ribonucleoprot. hom. | AW189878 |
| −2.26 0.14 | −2.16 0.08 | Ubiquitin carrier prot. E2-C | AW536176 |
| −2.19 0.17 | −2.2 0.09 | BAC 10818 cont. the Ercc-4 gene | AA407398 |
| −1.67 0.17 | −2.06 0.11 | Ring finger prot. 14 (Rnf14) | NM_020012 |
| −1.67 0.14 | −1.95 0.16 | RNA1 homolog (Fug1) | AW536168 |
| −1.36 0.05 | −1.63 0.14 | Similarities to BAT2 | AW545609 |
| −1.61 0.2 | −1.59 0.19 | NIPSNAP2 prot. | AA925098 |
| −1.57 0.21 | −1.61 0.11 | 14-3-3 prot. gamma-subtype | AW542425 |
| Energy metabolism | |||
| 3.53 0.37 | 3.22 1.28 | ATP synthase subunit d (Atp5jd) | NM_019383 |
| 2.63 0.38 | 2.49 0.47 | ATP synthase, H+ transport, F0 | NM_013795 |
| 4.47 1.78 | 4.3 0.74 | Cytochrome b | AF295545 |
| 5.24 2.11 | 4.12 0.31 | Cytochrome c oxidase subunit I | M27315 |
| 6.13 0.58 | 5.43 1.59 | Cytochrome c oxidase subunit II | AF378830 |
| 1.91 0.74 | 2.41 0.28 | Cytochrome c oxidase subunit VIc | X06146 |
| 3.77 1.23 | 4.56 0.83 | NADH dehydrog. hom./cyt. c. I | X13220 |
| 3.53 0.67 | 3.88 0.92 | Liver cytochrome c oxidase VIII | L48209 |
| 4.9 1.75 | 5.55 0.02 | NAD+-isocitrate dehydr., gamma | X74125 |
| 1.97 0.2 | 1.92 0.38 | Ubiquinol-cytochrome c red. (6.4kDa) | XM_009253 |
| Receptors, ion channels, neurotransmission | |||
| 1.92 0.12 | 2 0.25 | Vasopressin V1b receptor | AF314527 |
| 2.22 0.45 | 1.97 0.32 | Somatostatin | NM_012659 |
| −1.99 0.12 | −1.43 0.1 | Integrin alpha 5 | AW544851 |
| −2.65 0.06 | −4.03 0.05 | Putative E1–E2 ATPase | RSU78977 |
| Regulatory proteins kinases, phosphorylases | |||
| 1.92 0.06 | 2.01 0.38 | Prot. phosphatase 2A | NM_022209 |
| 1.8 0.28 | 1.86 0.16 | Prot. phosphatase 2, alpha isoform | NM_017039 |
| 4.75 nd | 7.14 0.64 | Transcription factor-like p. MRGX | AF100620 |
| 1.41 0.12 | 1.51 0.23 | Tax1 binding prot. TXBP151 | W35945 |
| −1.51 0.21 | −1.6 0.15 | STK-1 (serine/threonine kinase) | AA410169 |
| −2.06 0.1 | −2.42 0.08 | Nonreceptor tyrosine kinase 2 | W07947 |
| −1.46 0.09 | −1.56 0.09 | Transcriptional repressor deltaEF1 | D76433S |
| −1.73 0.16 | −2 0.03 | Goliath prot. hom. Zn-finger prot. | AA288977 |
| −2.26 0.02 | −2.22 0.11 | Kruppel-type zinc finger (C2H2) | AW540949 |
| −3.1 0.15 | −2.23 0.03 | Methyl CpG binding prot. 2 | NM_022673 |
| Unknown | |||
| 3.26 0.88 | 4.35 0.26 | Clone RP11-68L6 | AC008062 |
| 2.56 0.66 | 1.95 0.05 | MO25 prot. (LOC51719) | NM_016289 |
| 2.34 0.07 | 2.6 0.02 | Similar to CGI-89 prot. | XM_029457 |
| 7.14 2.85 | 6.6 1.75 | Cerebellum cDNA | AK005360 |
| 2.55 nd | 3.98 0.92 | RIKEN library, clone: 1300006O23 | AK004920 |
| 4.34 1.86 | 5.3 0.66 | Clone: 2010305H07 | AK008527 |
| 1.5 0.05 | 2.35 0.19 | RIKEN cDNA 6330579B17 gene | NM_026494 |
| 4.63 1.45 | 4.58 0.23 | No hits found | |
| 2.02 0.09 | 2.44 0.71 | No hits found | |
| 5.97 1.6 | 5.73 1.38 | No hits found | |
| 5.92 1.94 | 6.05 0.05 | No hits found | |
| 5.18 2.22 | 6.61 1.24 | No hits found | |
| −1.82 0.21 | −2.03 0.23 | EST (A. Thaliana) | AA409629 |
| −2.11 0.18 | −2.29 0.24 | Genomic 142000013386055 | AA409609 |
| −1.96 0.17 | −1.86 0.22 | EST | AA288548 |
| −2.66 0.03 | nd nd | BAC RP5-1185J21 | AW544929 |
| −2.04 0.12 | −2.59 0.04 | BAC clone RP11-319F3 | AC006039 |
| −2.92 0.07 | −2.3 0.14 | Clone PLACE1004814 | AW536179 |
| −2.32 0.06 | −2.07 0.13 | CGI-121 prot. | AA409886 |
| −2.25 0.19 | −2.54 0.05 | Clone RP11-497124 | AW544503 |
| −4.98 0.08 | −4.63 0.02 | Cosmid clone U39B3 | AW545277 |
| −1.74 0.08 | −2.35 0.09 | HSPC016 mRNA | AF077202 |
| −1.61 0.09 | −1.71 0.21 | Clone 705O1 | AP000845 |
| −2.15 0.13 | −3 0.1 | Clone RP3-419C19 | AW544861 |
| −1.76 0.05 | −1.64 0.05 | EST clone RP4-622L5 | AW544872 |
| −2.73 0.08 | 1.14 nd | Clone rp21-580p20 | AA409442 |
| −2.16 0.2 | −2.44 0.29 | Clone ct7-326b16 | AA409624 |
| −2.08 0.36 | −1.62 0.08 | Clone 45N8 | AW544672 |
| −1.56 0.11 | −1.74 0.14 | Unknown EST | AA396314 |
nd, not determined; EST, expressed sequence tag; BAC, bacterial artificial chromosome.