Table 4.
Prognostic factors for 3-year mortality in patients with systemic autoimmune rheumatic diseases interstitial lung disease in advanced GAP (GAP stage II or III).
| Univariate | Multivariate | |||
|---|---|---|---|---|
| Hazard Ratio (95% CI) | p-value | Hazard Ratio (95% CI) | p-value | |
| Age | ||||
| ≤ 60 | Ref | |||
| 61–65 | 4.340 (0.866–21.755) | 0.074 | ||
| ≥ 65 | 2.792 (0.633–12.305) | 0.175 | ||
| Male sex | 0.984 (0.425–2.278) | 0.969 | ||
| FVC, predicted % | ||||
| > 75 | Ref | |||
| 50–75 | 2.169 (0.288–16.324) | 0.452 | ||
| < 50 | 1.389 (0.162–11.904) | 0.764 | ||
| DLco, predicted % | ||||
| > 55 | Ref | |||
| 36–55 | 3.430 (0.447–26.289) | 0.236 | ||
| ≤ 35 | 3.516 (0.443–27.877) | 0.234 | ||
| *PPF | 2.131 (0.875–5.191) | 0.096 | 2.190 (0.897–5.348) | 0.085 |
| *Exertional hypoxia and UIP pattern | 2.473 (1.002–6.102) | 0.049 | 2.539 (1.024–6.295) | 0.044 |
Significant values are in italics.
FVC, forced vital capacity; DLco, diffusing capacity of the lungs for carbon monoxide; PPF, progressive pulmonary fibrosis; UIP, usual interstitial pneumonia.
*Included in the multivariate analysis.