Table 1.
Relationship between the IgSF11 signal and clinicopathological factors in patients with melanoma (n = 187)
| Parameter | Total | Low IgSF11 | High IgSF11 | p-value | ||||
|---|---|---|---|---|---|---|---|---|
| (n = 130) | (n = 57) | |||||||
| Age | 0.890 | |||||||
| < 70 | 90 | (48.1) | 63 | (48.4) | 27 | (44.8) | ||
| ≥ 70 | 97 | (51.8) | 67 | (51.5) | 30 | (55.2) | ||
| Gender | 0.288 | |||||||
| Male | 94 | (50.2) | 62 | (47.6) | 32 | (56.1) | ||
| Female | 93 | (49.7) | 68 | (52.3) | 25 | (43.8) | ||
| Tumor size (cm) | 0.565 | |||||||
| < 10 | 12 | (6.4) | 7 | (5.3) | 5 | (8.7) | ||
| < 20 | 84 | (44.9) | 59 | (45.3) | 25 | (43.8) | ||
| < 30 | 28 | (14.9) | 18 | (13.8) | 10 | (17.5) | ||
| < 40 | 32 | (17.1) | 26 | (20.0) | 6 | (10.5) | ||
| ≥ 40 | 22 | (11.7) | 13 | (10.0) | 9 | (15.7) | ||
| Unknown | 9 | (4.8) | 7 | (5.3) | 2 | (3.5) | ||
| Clark’s level | < 0.001 | |||||||
| I | 33 | (17.6) | 33 | (25.3) | 0 | (0.0) | ||
| II | 28 | (14.9) | 24 | (18.4) | 4 | (7.0) | ||
| III | 30 | (16.0) | 16 | (12.3) | 14 | (24.5) | ||
| IV | 51 | (27.2) | 29 | (22.3) | 22 | (38.5) | ||
| V | 37 | (19.7) | 25 | (19.2) | 12 | (21.0) | ||
| Unknown | 8 | (4.2) | 3 | (2.3) | 5 | (8.7) | ||
| Budding | 0.020 | |||||||
| < 5 | 33 | (17.6) | 25 | (19.2) | 8 | (14.0) | ||
| ≥ 5 | 75 | (25.1) | 39 | (30.0) | 36 | (63.1) | ||
| Unknown | 18 | (9.6) | 9 | (6.9) | 9 | (15.7) | ||
| Clark’s level I/II | 61 | (32.6) | 57 | (43.8) | 4 | (7.01) | ||
| Spindle cells | 0.095 | |||||||
| (–) | 157 | (83.9) | 113 | (86.9) | 44 | (77.1) | ||
| (+) | 30 | (16.0) | 17 | (13.0) | 13 | (22.8) | ||
| Lymph node metastasis | 0.088 | |||||||
| (–) | 128 | (68.4) | 93 | (71.5) | 35 | (61.4) | ||
| (+) | 41 | (21.9) | 24 | (18.4) | 17 | (29.8) | ||
| Unknown | 18 | (9.6) | 13 | (10.0) | 5 | (8.7) | ||
| Distant metastasis | 0.137 | |||||||
| (–) | 164 | (87.7) | 114 | (87.6) | 50 | (87.7) | ||
| (+) | 7 | (3.7) | 3 | (2.3) | 4 | (7.0) | ||
| Unknown | 16 | (8.5) | 13 | (10.0) | 3 | (5.2) | ||
| TNM stage | 0.030 | |||||||
| 0/I/II | 123 | (65.7) | 91 | (70.0) | 32 | (56.1) | ||
| III/IV | 49 | (26.2) | 28 | (21.5) | 21 | (36.8) | ||
| Unknown | 15 | (8.0) | 11 | (8.4) | 4 | (7.0) | ||
| BRAFV600E gene mutation | 0.642 | |||||||
| (–) | 23 | (12.2) | 16 | (12.3) | 7 | (12.2) | ||
| (+) | 9 | (4.8) | 7 | (5.3) | 2 | (3.5) | ||
| Unknown | 155 | (82.8) | 107 | (82.3) | 48 | (84.2) | ||
| Recurrence | 0.082 | |||||||
| (–) | 119 | (63.6) | 88 | (67.6) | 31 | (54.3) | ||
| (+) | 68 | (36.3) | 42 | (32.3) | 26 | (45.6) | ||