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ClustalW alignment of hSERT amino acid sequence versus other species of SERT and other biogenic amine transporters. Gly56 is conserved in mammalian species of SERT (A). Ile425 is conserved in all SERT proteins from human to Drosophila (B). Phe465 is conserved in all species shown for all monoamine transporters and is also conserved in glycine, γ-aminobutyric acid, and creatine transporters (C). Leu550 is conserved in all monoamine transporters from human to Drosophila (D).
