Figure 3.
Altered basal 5-HT transport activity and regulation associated with the Gly56Ala variant. [3H]5-HT (5HT) and [3H]L-glutamate (Glu) transport activities were defined as described in the “Subjects and Methods” section. A, 5-HT transport activity of EBV-transformed lymphocyte cell lines by genotype (G=Gly56; A=Alanine56). B, L-glutamate transport activity of the lines tested in panel A. C, Normalized 5-HT transport activity, with an individual cell lines 5-HT transport activity divided by its L-glutamate transport activity. D, Average by genotype of the values shown in panel C. An asterisk (*) denotes P<.05 (student’s t test) compared with Gly56 cell lines.