Fig. 4.
DCVIP-induced Tr prevent autoimmunity. (a) Therapeutic effect on arthritis. CIA (H-2q) or EAE mice (H-2b) with established disease were treated with syngeneic CII- and MOG-specific Trcontrol (○) or with different doses of CII- or MOG-specific TrVIP (106 cells, ▾ ;5 × 105 cells, ▿;5 × 104 cells, ▪). Untreated mice (•) were used as CIA and EAE controls. Clinical score was determined (n=10). (b) Untreated CIA/EAE mice or CIA/EAE mice injected with TrVIP and treated with control Ig, anti-IL10, anti-TGFβ, or anti-IL10 plus anti-TGFβ Abs. Clinical score was measured at the peak of the disease (n = 10).