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. 2005 Sep 12;102(38):13479–13483. doi: 10.1073/pnas.0506068102

Fig. 5.

Fig. 5.

αvβ8 and Band 4.1B colocalize in neural cells in the embryonic and postnatal central nervous system. (A-C) Band 4.1B is expressed on embryonic neuroepithelial processes (arrows in A), as shown by colocalization with nestin (arrows in B and C). (D-F) Band 4.1B (D) and β8 integrin (E) colocalize (F) on neuronal cell bodies and axons in the embryonic hindbrain. Arrows (D-F) show axonal coexpression. (G-I) Band 4.1B (G) and β8 (H) are expressed on axons and colocalize (I) at axonal membranes in the adult brainstem. Areas in dashed boxes highlight Band 4.1B and β8 colocalization (G-I Insets) at higher magnification. (J-L) Band 4.1B (J) and β8 integrin (K) colocalize (L) to axons in the adult cerebellum. Band 4.1B is also expressed in neuronal cell bodies (arrows in J and L) where β8 integrin is absent (arrow in K). For all colocalization experiments, Band 4.1B was detected with a goat polyclonal antibody (D, G, and J), and β8 was detected with a rabbit polyclonal antibody (E, H, and K).