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HVEM and LIGHT interactions within the TNFR and Ig superfamily. TNF-family ligands usually exist as trimers, and the receptors are also trimeric in their ligand-bound form, although higher order oligomers are possible (12). The oligomerization state of HVEM bound to BTLA or LIGHT is unknown. The networked interactions of this cosignaling family suggest that interference with one receptor/ligand interaction may have a domino effect by freeing up other interacting partners.
