Figure 1.

(A) Inhibitory effects of R. rhizoma on CT-catalyzed ADP-ribosylation. CTA (1 μg) was added with the indicated amounts of R. rhizoma (●), RG-tannin (▴), epigallocatechin gallate (■), emodin (○), and sennidine A (▵). Values represent the average of duplicate tubes from one experiment representative of three. (B) Effects of R. rhizoma on CT-induced fluid accumulation in ileal loops. Each mouse ileal loop was injected with 0.1 ml of a solution containing 100 ng of CT, and the indicated amounts of R. rhizoma (●), RG-tannin (▴), epigallocatechin gallate (■), and sennidine A (○). The mice were killed at 6 h and the fluid accumulation ratio (mg/cm) was calculated. Values represent means ± SD for five determinations.