Table 1.

Hematologic parameters, spleen/body weight ratios, and venular hemodynamics

Genotype	Leukocytes, ×103/μl	Hematocrit, %	Platelets, ×103/μl	Spleen/body weight ratios, g/g × 10−3	VRBC, mm/s		Venular diameters, μm
					IVM 1	IVM 2	IVM 1	IVM 2
WT	4.3  ± 0.6	41.1  ± 1.5	722  ± 56	2.5  ± 0.1	2.3  ± 0.1	2.4  ± 0.2	21.9  ± 0.8	21.8  ± 1.0
SA	7.4  ± 1.8	33.4  ± 2.1	1364  ± 126†	2.9  ± 0.1*	2.2  ± 0.1	2.0  ± 0.1	20.2  ± 1.2	21.7  ± 1.2
SS	22.3  ± 2.4*	13.1  ± 0.8†	287  ± 21†	27.3  ± 2.7‡	2.2  ± 0.1	0.6  ± 0.2‡	20.9  ± 1.3	24.9  ± 1.8
SSP/E −/−	72.1  ± 11.4†	18.2  ± 4.7†	331  ± 72*	36.0  ± 3.3‡	2.6  ± 0.1	1.9  ± 0.1	20.4  ± 1.5	20.3  ± 1.2

Blood counts were determined using an automatic cell counter. Centerline velocities (V_RBC) were measured in real time by using an optical doppler velocimeter. Venular diameters were assessed using a video caliper. n = 4–9 mice for blood counts; n = 23–41 venules from 4–5 mice for hemodynamic characteristics. 

^*, P < 0.05 compared to WT animals.  

^†, P < 0.001 compared to WT animals.  

^‡, P < 0.0001 compared to WT animals.