Table 1.

Sister chromatid exchanges (SCE), average generation time (AGT), and mitotic index (MI) induced by beta-sitosterol (BS) and pteropodine (PT) in mouse bone marrow cells. MO = mineral oil (0.4 mL added to each mouse). DW = distilled water (0.4 mL added to each mouse). DR = doxorubicin. M1, M2, M3 = cells in first, second, and third cellular division. AGT = 21 (M1+2M2+3M3) (100).

Agent	Dose	SCE	M1	M2	M3	AGT	MI
	mg/kg	$\overline{X}$ ± SD	%	%	%	$\overline{X}$ ± SD	$\overline{X}$ ± SD
MO	—	1.88 ± 0.12	38	48	14	12.15 ± 0.23	5.73 ± 0.34
BS	200	2.12 ± 0.28	32	53	15	12.14 ± 0.17	5.66 ± 0.29
BS	400	1.54 ± 0.21	36	50	14	12.45 ± 0.12	5.70 ± 0.18
BS	600	1.34 ± 0.24	34	55	11	12.55 ± 0.10	5.58 ± 0.33
BS	1000	1.0 ± 0.34	33	52	15	12.35 ± 0.18	6.03 ± 0.22
DR	10	*16.83 ± 0.42	33	58	9	12.37 ± 0.31	6.43 ± 0.41
DW	—	2.51 ± 0.12	34	51	15	12.45 ± 0.23	5.94 ± 0.19
PT	100	1.15 ± 0.16	35	51	14	12.36 ± 0.14	5.97 ± 0.26
PT	200	2.03± 0.27	37	50	13	12.46 ± 0.21	5.80 ± 0.38
PT	300	1.08 ± 0.57	34	51	15	12.25 ± 0.33	6.70 ± 0.18
PT	600	1.44 ± 0.22	34	49	17	12.63 ± 0.16	7.13 ± 0.17
DR	10	*14.06 ± 0.68	39	50	11	12.47 ± 0.26	6.16 ± 0.68

*Statistically significant difference with respect to the result obtained in the negative control group. ANOVA and Student t tests, P ≤ .05.