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. Author manuscript; available in PMC: 2005 Sep 21.
Published in final edited form as: Hum Mol Genet. 2004 Dec 22;14(4):483–492. doi: 10.1093/hmg/ddi045

Figure 4.

Figure 4

Analysis of GABRB3 expression in mouse and human brain. (A) Immunoblot analysis of GABRB3 expression (anti-GABRB3, Affinity Bioreagents, recognizing all known isoforms) shows lower expression in Mecp2−/+ and Mecp2−/y adult mouse brain compared with controls. Combined GAPDH-normalized results from eight different Mecp2−/+ and six different Mecp2+/+ adult brain samples from Mecp2tm1.1Bird and Mecp2tm1.1Jae strains were significantly lower than wild-type controls (P < 0.01). (B) Representative immunoblot analyses of GABRB3 and GAPDH in AS, RTT, autism and control (NS) cerebral samples with GABRB3/GAPDH ratios shown. Replicate immunoblot results for all samples and significance tests are shown in Table 1. Additional information about postmortem brain samples used in these studies is provided online (Supplementary Material, Table S1).