Skip to main content
. Author manuscript; available in PMC: 2005 Sep 21.
Published in final edited form as: Viral Immunol. 2005;18(1):41–78. doi: 10.1089/vim.2005.18.41

FIG. 8.

FIG. 8

Role of glucocorticoids in protection against cytokine (TNF)–mediated lethality. (A) Adrenalectomized (ADX) mice were vehicle injected (squares) or infected with MCMV (1 × 105 PFU/mouse) 5 days following surgery and either not given (circles) or given corticosterone in 0.9% saline as drinking water at either 30 μg/mL (diamonds) or 300 μg/mL (triangles). Control mice received vehicle-treated water. Denoted p value represents significant differences between corticosterone and vehicle-treated MCMV-infected ADX mice. (B) Control (circles) or anti-TNF (triangles) antibodies (Abs) were administered 8–10 h before infection of ADX mice. Denoted p value represents significant differences between TNF and control Ab-treated MCMV-infected ADX mice. Data are presented as means ± SEM. Results are significant at **p < 0.01. Reprinted by permission from Silverman et al. (274,254).