Skip to main content
. Author manuscript; available in PMC: 2006 Jul 1.
Published in final edited form as: Cancer Res. 2005 Jul 1;65(13):5620–5627. doi: 10.1158/0008-5472.CAN-05-0536

Figure 6.

Figure 6

A. The rate of tumor formation in one year old JPO1/CDCA7 transgenic mice as compared to non-transgenic, age-matched littermates. Data is compiled from all 4 founders. Tumors observed were, for non-transgenic animals: pancreatic lymphoma (n=1), mesenteric lymphoma (n=2); for transgenic animals: pancreatic lymphoma (n=2), thymic lymphoma (n=1), mesenteric lymphoma(n=1), histiocytic sarcoma (n=2), intestinal adenocarcinoma (n=2), stomach papilloma (n=1), and bronchoalveolar adenoma (n=1). Note that one transgenic mouse had both a pancreatic and a mesenteric lymphoma, which were combined as one for determination of incidence.

B. Representative histology from necropsy of JPO1/CDCA7 transgenic mice. The left panel shows a lymphoma in pancreatic lymph node. Mitoses are indicated by black arrows, prominent nucleoli by white arrows, and a vesicular nucleus by the arrowhead. The panel on the right shows histiocytic sarcoma present in spleen. Black arrows indicate giant cells on a background of histiocytes, and the white arrow points out mitosis.