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In vivo topo II cleavage, DNase I HS sites and genomic breakpoints in ETO in t(8;21). The vertical boxes and lines represent exons, genomic DNA probes, and BamHI (B), BglII (G) and SacI (S) restriction sites. Arrows and arrowheads at the bottom represent topo II cleavage and DNase I HS sites. The numbers represent the distance (bp) of the breakpoints to exon 1a. K: Kasumi 1 cell line.
