PCR detection of the transgene in peripheral blood of the dog. A
fragment of the bicistronic γc-IRES-MDR1 cDNA was
amplified from 200 ng of DNA with primers specific for the γc (sense
primer) and IRES (antisense primer). As a control, a fragment from the
canine corticotrophin-releasing hormone gene was amplified under
identical conditions. Shown are analyses from blood at the following
time points: 17 months post-BMT (lane 1), 25 months (lane 2), 27 months
(lane 3), 28 months (lane 4), and 43 months post-BMT (lane 5). As a
negative control, blood from a normal, untreated animal is shown in
lane 6.