Table 1.
The emerging roles of EV-ncRNAs between MSCs and different cancer types.
| ncRNA | Source Cells | Target Cells | EVs Types | Expression | Function | Mechanism | Refs |
|---|---|---|---|---|---|---|---|
| circ_6790 | MSCs | PDAC | Exosomes | Up | Cancer inhibition | Chromatin regulation | [77] |
| LINC00622 | MSCs | Neuroblastoma | EVs | Up | Cancer inhibition | Transcriptional regulation | [78] |
| lncRNA PTENP1 | MSCs | Gliomas | Exosomes | Down | Cancer inhibition | Sponging miRNA | [95] |
| LncRNA RN7SK | MSCs | TNBC | Exosomes | Up | Cancer inhibition | Transcriptional regulation | [96] |
| lncRNA-SNHG3 | MSCs | Breast cancer | Exosomes | Up | Cancer promotion | Sponging miRNA | [97] |
| lncRNA C5orf66 | MSCs | HCC | Exosomes | Up | Cancer inhibition | Sponging miRNA | [98] |
| lncRNA FAM99B | MSCs | HCC | Exosomes | Down | Cancer inhibition | — | [99] |
| circ_0030167 | MSCs | PC | Exosomes | Up | Cancer inhibition | Sponging miRNA | [100] |
| lncRNA NEAT1 | MSCs | PC | EVs | Up | Cancer promotion | Sponging miRNA | [101] |
| lncRNA-Sox2ot | Cancer cells | PDAC | Exosomes | Up | Cancer promotion | Sponging miRNA | [102] |
| lncRUNX2-AS1 | Cancer cells | MSCs | Exosomes | Up | Cancer inhibition | Transcriptional regulation | [103] |
| LINC00461 | MSCs | MM | Exosomes | Up | Cancer promotion | Sponging miRNA | [104] |
| lncRNA PVT1 | MSCs | Osteosarcoma | Exosomes | Up | Cancer promotion | Sponging miRNA | [105] |
| lncRNA XIST | MSCs | Osteosarcoma | Exosomes | Up | Cancer promotion | Sponging miRNA | [106] |
| lncRNA MALAT1 | MSCs | Osteosarcoma | EVs | Up | Cancer promotion | Sponging miRNA | [107] |
| lncRNA NORAD | MSCs | Osteosarcoma | EVs | Up | Cancer promotion | Sponging miRNA | [108] |
| lncRNA NORAD | MSCs | Osteosarcoma | Exosomes | Up | Cancer promotion | Sponging miRNA | [109] |
| circNRIP1 | MSCs | Osteosarcoma | EVs | Up | Cancer promotion | Sponging miRNA | [110] |
| LINC00847 | MSCs | Ewing’s sarcoma | EVs | Down | Cancer inhibition | Sponging miRNA | [111] |
| CircRNA_100395 | MSCs | Lung cancer | Exosomes | Down | Cancer inhibition | Sponging miRNA | [112] |
| LINC01559 | MSCs | Gastric cancer | Exosomes | Up | Cancer promotion | Sponging miRNA | [113] |
| Circ_00004303 | Cancer cells | MSCs | Exosomes | Up | Cancer promotion | Sponging miRNA | [114] |
| circ670 | Cancer stem cells | Gastric cancer | Exosomes | Up | Cancer promotion | — | [115] |
| lncRNA NEAT1 | MSCs | Melanoma | EVs | Up | Cancer promotion | Sponging miRNA | [116] |
| LncRNA NEAT1 | Cancer cells | MSCs | EVs | Up | Cancer promotion | Sponging miRNA | [117] |
| lncRNA PTENP1 | MSCs | Bladder cancer | Exosomes | Up | Cancer inhibition | Sponging miRNA | [118] |
| circ_0037104 | MSCs | Cholangiocarcinoma | Exosomes | Down | Cancer inhibition | Sponging miRNA | [119] |
| lncRNA SNHG5 | Cancer cells | Acute myeloid leukemia | Exosomes | Up | Cancer promotion | mRNA stability | [120] |
Abbreviations: TNBC: triple negative breast cancer; HCC: hepatocellular carcinoma; MSCs: mesenchymal stem cells; PC: pancreatic cancer; MM: multiple myeloma; PDAC: pancreatic ductal adenocarcinoma.