Table 1.

Patient characteristics, lavage protein content and apparent molecular weight of SP-B and SP-C

Children	N (males)	Age (y)	Time of follow up (years), outcome	Protein (μg/ml)	SP-B Mr of band (kDa)	SP-C Mr of band (kDa)
without lung disease	15 (8)	5.4 (0.5–12)	not applicable	62 (21–275)	7.1 (5.9–11.6)	4.8 (4.3–5.8)
with chronic obstructive bronchitis	19 (13)	5.3 (1–15)	4 (0.3–10) years, 14/19 better, 3/19 same, 1/19 worse, 1/19 unknown	76 (17–207)	11.0 (8–13.5)	5.2 (3.9–5.6)
with no SP-B	6 (3)	neonates	5 pts [2–6] died at 0.3 (0.1–0.4) years, pt [1] alive with corticosteroids	318* (131–2048)	no SP-B bands in any pt	5.6 (3.6–6.5) pt [4] no SP-C
with pulmonary alveolar proteinosis	15 (9)	1.4 (0.6–4)	Pts [6,10,14,15] died at ages 1.3 and 1.7 years and at 4 and 5 months of age. 11/15 alive with repetitive whole lung lavages and oxygen-dependence	495** (87–2099)	10.5 (8.8–12.5)	4.8 (3.6–5.4)
with chronic respiratory distress of unknown cause	7 (7)	neonates, one subject 4 months	4 died at age 8 days to 4 months, 3 [3,6,7] lost on follow up	449* (184–474)	9.7 (6.3–11.2)	5.6 (4.3–7)

All data are medians and range, n.d. = not determined. Significantly higher compared to children without lung disease or children with obstructive bronchitis, which did not differ *p < 0.01, **p < 0.001 by Kruskal-Wallis-Analysis followed by Dunn's multiple comparisons test