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. 2002 Feb 26;99(5):3258–3263. doi: 10.1073/pnas.052704499

Figure 4.

Figure 4

T4 treatment reduces proliferation and expression of precursor-associated markers in the SVZ of EAE animals. (A) Western blot and quantitative analysis of Ki67 protein in the SVZ. T4 treatment reduces the strong up-regulation of Ki67 protein in the SVZ of EAE-affected rats. (B) Confocal images of codistribution of Ki67-IR and nestin-immunoreactivity in the SVZ of control, EAE, and EAE T4-treated rats. Semiquantitative analysis has been performed on images merging 10 sections, 0.375 μm thick. Images and quantitative analysis illustrates up-regulation of nestin expression in EAE, and its reduction by T4 treatment. (Magnification: ×250.) Statistical analysis: Anova and Dunnett test, *, P < 0.05, **, P < 0.01; Student's t test for T4 effect, a, P < 0.05, b, P < 0.01.