Table 1. Best fit estimates of parameters obtained by fitting the winning model (Model D, linear model with CD95int T_SCM first) to the labelling, telomere and YFV data. Interquartile range (estimated by bootstrapping the data) shown in square brackets below the corresponding estimates. Note, the clonal half-life corresponds to the half-life of the clone (ln2/d-p) not the half-life of the cell as is typically reported (ln2/d). Best fit estimates for the other 4 models are provided in Tables G–J in S2 Text. We found that CD95int TSCM cells proliferated much more slowly than CD95hi TSCM cells with an average proliferation rate of 0.0008 per day (equivalent to one division every 3.4 yrs) whereas CD95hi TSCM cells had an average proliferation rate of 0.002 per day (equivalent to one division every 1.4 yrs). The data in this table can be found in S1 Data.

Id	pN (day−1)	p1 (day−1)	p2 (day−1)	ΔN (day−1)	Δ1 (day−1)	k	A (% of CD8)	Clonal half-life CD95int (days)	Clonal half-life CD95hi (days)
DW19	0.00023 [0.00022, 0.00034]	0.0013 [0.0011, 0.0019]	0.004 [0.004, 0.06]	1 × 10−6 [2 × 10−9, 1 × 10−6]	0.001 [0.001, 0.008]	1.8 [1.3, 10.0]	0.04 [0.03, 0.04]	5231 [3717, 18206]	194 [37, 209]
DW20	0.00031 [0.00028, 0.00038]	0.0008 [0.0006, 0.0008]	0.002 [0.002, 0.046]	5 × 10−9 [2 × 10−10, 2 × 10−7]	0.001 [0.001, 0.005]	10.3 [4.0, 15.0]	0.03 [0.03, 0.04]	5409 [3213, 12307]	590 [107, 633]
DW25	0.00032 [0.00030, 0.00034]	0.0003 [0.0002, 0.0004]	0.001 [0.001, 0.001]	4 × 10−10 [4 × 10−10, 8 × 10−10]	0.001 [0, 0.001]	15.0 [15.0, 15.0]	0.03 [0.03, 0.03]	2812 [1856, 3567]	1346 [1225, 3338]
MEDIAN	0.00031	0.0008	0.002	5 × 10 −9	0.001	10.3	0.03	5231	590